Depo Provera is somewhat popular in the trans community. It’s most likely to stop periods, which is a life-saver for trans folk who are highly dysphoric during that time. It’s covered by most insurance and is far easier to get than T, as well, so it’s helpful for those who either don’t want T or who can’t get on it yet. (also, although this is aimed at the trans community, it’s certainly useful information for cis women considering depo as well)
There’s a not unheard of side effect, though, that I not a lot of people talk about. Namely: prolonged periods, sometimes lasting months.